Endoplasmic Reticulum Oxidoreductin-1α (Ero1α) Improves Folding and Secretion of Mutant Proinsulin and Limits Mutant Proinsulin-induced Endoplasmic Reticulum Stress

Upon chronic up-regulation of proinsulin synthesis, misfolded proinsulin can accumulate in the endoplasmic reticulum (ER) of pancreatic β-cells, promoting ER stress and type 2 diabetes mellitus. In Mutant Ins-gene-induced Diabetes of Youth (MIDY), misfolded mutant proinsulin impairs ER exit of co-ex...

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Autores principales: Wright, Jordan, Birk, Julia, Haataja, Leena, Liu, Ming, Ramming, Thomas, Weiss, Michael A., Appenzeller-Herzog, Christian, Arvan, Peter
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Molecular Bases of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829414/
https://ncbi.nlm.nih.gov/pubmed/24022479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.510065
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