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Structural Basis of Mycobacterial Inhibition by Cyclomarin A

Cyclomarin A (CymA) was identified as a mycobactericidal compound targeting ClpC1. However, the target was identified based on pulldown experiments and in vitro binding data, without direct functional evidence in mycobacteria. Here we show that CymA specifically binds to the N-terminal domain of Clp...

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Detaylı Bibliyografya
Asıl Yazarlar: Vasudevan, Dileep, Rao, Srinivasa P. S., Noble, Christian G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2013
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829403/
https://ncbi.nlm.nih.gov/pubmed/24022489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.493767
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