Structural Basis for Selective Small Molecule Kinase Inhibition of Activated c-Met

The receptor tyrosine kinase c-Met is implicated in oncogenesis and is the target for several small molecule and biologic agents in clinical trials for the treatment of cancer. Binding of the hepatocyte growth factor to the cell surface receptor of c-Met induces activation via autophosphorylation of...

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Hlavní autoři: Rickert, Keith W., Patel, Sangita B., Allison, Timothy J., Byrne, Noel J., Darke, Paul L., Ford, Rachael E., Guerin, David J., Hall, Dawn L., Kornienko, Maria, Lu, Jun, Munshi, Sanjeev K., Reid, John C., Shipman, Jennifer M., Stanton, Elizabeth F., Wilson, Kevin J., Young, Jonathon R., Soisson, Stephen M., Lumb, Kevin J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064177/
https://ncbi.nlm.nih.gov/pubmed/21247903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.204404
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