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Structural Basis of Mycobacterial Inhibition by Cyclomarin A
Cyclomarin A (CymA) was identified as a mycobactericidal compound targeting ClpC1. However, the target was identified based on pulldown experiments and in vitro binding data, without direct functional evidence in mycobacteria. Here we show that CymA specifically binds to the N-terminal domain of Clp...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3829403/ https://ncbi.nlm.nih.gov/pubmed/24022489 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.493767 |
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