Structural basis for ADP-dependent glucokinase inhibition by 8-bromo–substituted adenosine nucleotide

In higher eukaryotes, several ATP-utilizing enzymes known as hexokinases activate glucose in the glycolysis pathway by phosphorylation to glucose 6-phosphate. In contrast to canonical hexokinases, which use ATP, ADP-dependent glucokinase (ADPGK) catalyzes noncanonical phosphorylation of glucose to g...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Grudnik, Przemysław, Kamiński, Marcin M., Rembacz, Krzysztof P., Kuśka, Katarzyna, Madej, Mariusz, Potempa, Jan, Dawidowski, Maciej, Dubin, Grzegorz
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052215/
https://ncbi.nlm.nih.gov/pubmed/29784881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001562
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