Inhibition of HDAC6 Deacetylase Activity Increases Its Binding with Microtubules and Suppresses Microtubule Dynamic Instability in MCF-7 Cells

The post-translational modification of tubulin appears to be a highly controlled mechanism that regulates microtubule functioning. Acetylation of the ϵ-amino group of Lys-40 of α-tubulin marks stable microtubules, although the causal relationship between tubulin acetylation and microtubule stability...

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Hlavní autoři: Asthana, Jayant, Kapoor, Sonia, Mohan, Renu, Panda, Dulal
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829339/
https://ncbi.nlm.nih.gov/pubmed/23798680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.489328
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