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Kinetic suppression of microtubule dynamic instability by griseofulvin: Implications for its possible use in the treatment of cancer

The antifungal drug griseofulvin inhibits mitosis strongly in fungal cells and weakly in mammalian cells by affecting mitotic spindle microtubule (MT) function. Griseofulvin also blocks cell-cycle progression at G(2)/M and induces apoptosis in human tumor cell lines. Despite extensive study, the mec...

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Detalhes bibliográficos
Main Authors: Panda, Dulal, Rathinasamy, K., Santra, Manas K., Wilson, Leslie
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1174985/
https://ncbi.nlm.nih.gov/pubmed/15985553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501821102
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