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Stabilization of microtubule dynamics by estramustine by binding to a novel site in tubulin: A possible mechanistic basis for its antitumor action

The cellular targets for estramustine, an antitumor drug used in the treatment of hormone-refractory prostate cancer, are believed to be the spindle microtubules responsible for chromosome separation at mitosis. Estramustine only weakly inhibits polymerization of purified tubulin into microtubules b...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Panda, Dulal, Miller, Herbert P., Islam, Khalid, Wilson, Leslie
פורמט: Artigo
שפה:Inglês
יצא לאור: The National Academy of Sciences of the USA 1997
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC23400/
https://ncbi.nlm.nih.gov/pubmed/9380674
תגים: הוספת תג
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