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Transformation of taxol-stabilized microtubules into inverted tubulin tubules triggered by a tubulin conformation switch

Bundles of taxol-stabilized microtubules (MTs) – hollow tubules comprised of assembled αβ-tubulin heterodimers – spontaneously assemble above a critical concentration of tetravalent spermine and are stable over long times at room temperature. Here we report that at concentrations of spermine several...

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Hlavní autoři: Ojeda-Lopez, Miguel A., Needleman, Daniel J., Song, Chaeyeon, Ginsburg, Avi, Kohl, Phillip A., Li, Youli, Miller, Herbert P., Wilson, Leslie, Raviv, Uri, Choi, Myung Chul, Safinya, Cyrus R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946914/
https://ncbi.nlm.nih.gov/pubmed/24441880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmat3858
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