Conformational changes in tubulin in GMPCPP and GDP-taxol microtubules observed by cryoelectron microscopy

Microtubules are dynamic polymers that stochastically switch between growing and shrinking phases. Microtubule dynamics are regulated by guanosine triphosphate (GTP) hydrolysis by β-tubulin, but the mechanism of this regulation remains elusive because high-resolution microtubule structures have only...

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Bibliographic Details
Main Authors: Yajima, Hiroaki, Ogura, Toshihiko, Nitta, Ryo, Okada, Yasushi, Sato, Chikara, Hirokawa, Nobutaka
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2012
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413364/
https://ncbi.nlm.nih.gov/pubmed/22851320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201201161
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