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Mechanism of the single-headed processivity: Diffusional anchoring between the K-loop of kinesin and the C terminus of tubulin

A motor-domain construct of KIF1A, a single-headed kinesin superfamily protein, was demonstrated to take more than 600 steps before detaching from a microtubule. However, its molecular mechanism remained unclear. Here we demonstrate the nucleotide-dependent binding between the lysine-rich, highly po...

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Bibliografske podrobnosti
Main Authors: Okada, Yasushi, Hirokawa, Nobutaka
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2000
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC15383/
https://ncbi.nlm.nih.gov/pubmed/10639132
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