Proapoptotic Bax and Bak Proteins Form Stable Protein-permeable Pores of Tunable Size

The Bcl-2 proapoptotic proteins Bax and Bak mediate the permeabilization of the mitochondrial outer membrane during apoptosis. Current models consider that Bax and Bak form pores at the mitochondrial outer membrane that are responsible for the release of cytochrome c and other larger mitochondrial a...

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Bibliographic Details
Main Authors: Bleicken, Stephanie, Landeta, Olatz, Landajuela, Ane, Basañez, Gorka, García-Sáez, Ana J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Membrane Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829170/
https://ncbi.nlm.nih.gov/pubmed/24100034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.512087
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