Distinct Specificity and Single-molecule Kinetics Characterize the Interaction of Pathogenic and Non-pathogenic Antibodies against Platelet Factor 4-Heparin Complexes with Platelet Factor 4

Heparin-induced thrombocytopenia (HIT) is a thrombotic complication of heparin therapy mediated by antibodies to complexes between platelet factor 4 (PF4) and heparin or cellular glycosaminoglycans. However, only a fraction of patients with anti-PF4-heparin antibodies develop HIT, implying that only...

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Main Authors: Litvinov, Rustem I., Yarovoi, Serge V., Rauova, Lubica, Barsegov, Valeri, Sachais, Bruce S., Rux, Ann H., Hinds, Jillian L., Arepally, Gowthami M., Cines, Douglas B., Weisel, John W.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Bases of Disease
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829155/
https://ncbi.nlm.nih.gov/pubmed/24097975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.481598
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