Arginase‐II Induces Vascular Smooth Muscle Cell Senescence and Apoptosis Through p66Shc and p53 Independently of Its l‐Arginine Ureahydrolase Activity: Implications for Atherosclerotic Plaque Vulnerability

BACKGROUND: Vascular smooth muscle cell (VSMC) senescence and apoptosis are involved in atherosclerotic plaque vulnerability. Arginase‐II (Arg‐II) has been shown to promote vascular dysfunction and plaque vulnerability phenotypes in mice through uncoupling of endothelial nitric oxide synthase and ac...

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Main Authors: Xiong, Yuyan, Yu, Yi, Montani, Jean‐Pierre, Yang, Zhihong, Ming, Xiu‐Fen
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Publishing Ltd 2013
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3828809/
https://ncbi.nlm.nih.gov/pubmed/23832324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000096
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