SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells

Unlike activated CD4(+) T cells, resting CD4(+) T cells are highly resistant to productive HIV-1 infection(1–8). Early after HIV-1 entry, a major block limits reverse transcription of incoming viral genomes. Here we show that the deoxynucleoside triphosphate triphosphohydrolase SAMHD1 prevents rever...

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Huvudupphovsmän: Baldauf, Hanna-Mari, Pan, Xiaoyu, Erikson, Elina, Schmidt, Sarah, Daddacha, Waaqo, Burggraf, Manja, Schenkova, Kristina, Ambiel, Ina, Wabnitz, Guido, Gramberg, Thomas, Panitz, Sylvia, Flory, Egbert, Landau, Nathaniel R, Sertel, Serkan, Rutsch, Frank, Lasitschka, Felix, Kim, Baek, König, Renate, Fackler, Oliver T, Keppler, Oliver T
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3828732/
https://ncbi.nlm.nih.gov/pubmed/22972397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2964
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