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Drive Against Hotspot Motifs in Primates Implicates the PRDM9 gene in Meiotic Recombination: We provide evidence that a rapidly evolving gene is involved in determining recombination hotspot locations in humans
Although present in both humans and chimpanzees, recombination hotspots, at which meiotic cross-over events cluster, differ markedly in their genomic location between the species. We report that a 13-bp sequence motif previously associated with the activity of 40% of human hotspots does not function...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3828505/ https://ncbi.nlm.nih.gov/pubmed/20044541 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1182363 |
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