A Novel Hap1–Tsc1 Interaction Regulates Neuronal mTORC1 Signaling and Morphogenesis in the Brain

Tuberous sclerosis complex (TSC) is a leading genetic cause of autism. The TSC proteins Tsc1 and Tsc2 control the mTORC1 signaling pathway in diverse cells, but how the mTORC1 pathway is specifically regulated in neurons remains to be elucidated. Here, using an interaction proteomics approach in neu...

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Detalhes bibliográficos
Main Authors: Mejia, Luis A., Litterman, Nadia, Ikeuchi, Yoshiho, de la Torre-Ubieta, Luis, Bennett, Eric J., Zhang, Chi, Harper, J. Wade, Bonni, Azad
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3828457/
https://ncbi.nlm.nih.gov/pubmed/24227713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2290-13.2013
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