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DNA Damage: Placing BRCA1 in the Proper Context

How does BRCA1’s evolutionarily conserved E3 ligase activity contribute to DNA damage responses? Genetically engineered cells containing a BRCA1 RING domain mutation have been used to identify Claspin as a new target of BRCA1 E3 ligase activity in response to specific forms of DNA damage.

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Détails bibliographiques
Auteurs principaux: Aressy, Bernadette, Greenberg, Roger A.
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3827951/
https://ncbi.nlm.nih.gov/pubmed/23017997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2012.07.046
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