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DNA Damage: Placing BRCA1 in the Proper Context
How does BRCA1’s evolutionarily conserved E3 ligase activity contribute to DNA damage responses? Genetically engineered cells containing a BRCA1 RING domain mutation have been used to identify Claspin as a new target of BRCA1 E3 ligase activity in response to specific forms of DNA damage.
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3827951/ https://ncbi.nlm.nih.gov/pubmed/23017997 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2012.07.046 |
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