Continuous Hypoxic Culturing of Human Embryonic Stem Cells Enhances SSEA-3 and MYC Levels

Low oxygen tension (hypoxia) contributes critically to pluripotency of human embryonic stem cells (hESCs) by preventing spontaneous differentiation and supporting self-renewal. However, it is not well understood how hESCs respond to reduced oxygen availability and what are the molecular mechanisms m...

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Autori principali: Närvä, Elisa, Pursiheimo, Juha-Pekka, Laiho, Asta, Rahkonen, Nelly, Emani, Maheswara Reddy, Viitala, Miro, Laurila, Kirsti, Sahla, Roosa, Lund, Riikka, Lähdesmäki, Harri, Jaakkola, Panu, Lahesmaa, Riitta
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3827269/
https://ncbi.nlm.nih.gov/pubmed/24236059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078847
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