Epigenetic Silencing of the Key Antioxidant Enzyme Catalase in Karyotypically Abnormal Human Pluripotent Stem Cells

Epigenomic regulation is likely to be important in the maintenance of genomic integrity of human pluripotent stem cells, however, the mechanisms are unknown. We explored the epigenomes and transcriptomes of human pluripotent stem cells before and after spontaneous transformation to abnormal karyotyp...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Konki, Mikko, Pasumarthy, Kalyan, Malonzo, Maia, Sainio, Annele, Valensisi, Cristina, Söderström, Mirva, Emani, Maheswara Reddy, Stubb, Aki, Närvä, Elisa, Ghimire, Bishwa, Laiho, Asta, Järveläinen, Hannu, Lahesmaa, Riitta, Lähdesmäki, Harri, Hawkins, R. David, Lund, Riikka J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766493/
https://ncbi.nlm.nih.gov/pubmed/26911679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22190
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