Progranulin Directly Binds to the CRD 2 and CRD3 of TNFR Extracellular Domains

We previously reported that PGRN directly bound to TNF receptors (TNFR) in vitro and in chondrocytes (Tang, et al, Science, 2011). Here we report that PGRN also associated with TNFR in splenocytes, and inhibited the binding of TNFα to immune cells. Proper folding of PGRN is essential for its binding...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Jian, Jinlong, Zhao, Shuai, Tian, Qingyun, Gonzalez-Gugel, Elena, Mundra, Jyoti Joshi, Uddin, Sardar MZ, Liu, Ben, Richbourgh, Brendon, Brunetti, Ryan, Liu, Chuan-ju
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3826980/
https://ncbi.nlm.nih.gov/pubmed/24070898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2013.09.024
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