Progranulin Directly Binds to the CRD 2 and CRD3 of TNFR Extracellular Domains

We previously reported that PGRN directly bound to TNF receptors (TNFR) in vitro and in chondrocytes (Tang, et al, Science, 2011). Here we report that PGRN also associated with TNFR in splenocytes, and inhibited the binding of TNFα to immune cells. Proper folding of PGRN is essential for its binding...

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Main Authors: Jian, Jinlong, Zhao, Shuai, Tian, Qingyun, Gonzalez-Gugel, Elena, Mundra, Jyoti Joshi, Uddin, Sardar MZ, Liu, Ben, Richbourgh, Brendon, Brunetti, Ryan, Liu, Chuan-ju
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3826980/
https://ncbi.nlm.nih.gov/pubmed/24070898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2013.09.024
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