Structural basis for distinct functions of the naturally occurring Cys mutants of human apolipoprotein A-I

HDL removes cell cholesterol and protects against atherosclerosis. ApoA-I provides a flexible structural scaffold and an important functional ligand on the HDL surface. We propose structural models for apoA-I(Milano) (R173C) and apoA-I(Paris) (R151C) mutants that show high cardioprotection despite l...

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Detalles Bibliográficos
Autores principales: Gursky, Olga, Jones, Martin K., Mei, Xiaohu, Segrest, Jere P., Atkinson, David
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2013
Materias:
Review
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3826673/
https://ncbi.nlm.nih.gov/pubmed/24038317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.R037911
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