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Structural Stability and Local Dynamics in Disease-Causing Mutants of Human Apolipoprotein A-I: What Makes the Protein Amyloidogenic?

ApoA-I, the major protein of plasma high-density lipoprotein, removes cellular cholesterol and protects against atherosclerosis. ApoA-I mutations can cause familial amyloidosis, a life-threatening disease wherein N-terminal protein fragments form fibrils in vital organs. To unveil the protein misfol...

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Bibliografiske detaljer
Udgivet i:J Mol Biol
Main Authors: Das, Madhurima, Wilson, Christopher J., Mei, Xiaohu, Wales, Thomas, Engen, John R., Gursky, Olga
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4744490/
https://ncbi.nlm.nih.gov/pubmed/26562506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.10.029
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