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Structural basis for distinct functions of the naturally occurring Cys mutants of human apolipoprotein A-I
HDL removes cell cholesterol and protects against atherosclerosis. ApoA-I provides a flexible structural scaffold and an important functional ligand on the HDL surface. We propose structural models for apoA-I(Milano) (R173C) and apoA-I(Paris) (R151C) mutants that show high cardioprotection despite l...
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| Главные авторы: | , , , , |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The American Society for Biochemistry and Molecular Biology
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3826673/ https://ncbi.nlm.nih.gov/pubmed/24038317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.R037911 |
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