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Cdkn1b overexpression in adult mice alters the balance between genome and tissue aging
Insufficient cell proliferation has been suggested as a potential cause of age related tissue dysgenesis in mammals. However, genetic manipulation of cell cycle regulators in the germ lines of mice results in changes in animal size but not progeroid phenotypes. Here we increase levels of the cyclin...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3825507/ https://ncbi.nlm.nih.gov/pubmed/24149709 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3626 |
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