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p31(comet) inactivates the chemically induced Mad2-dependent spindle assembly checkpoint and leads to resistance to anti-mitotic drugs
Mad2 is a key component of the spindle assembly checkpoint (SAC) that delays the onset of anaphase until all kinetochores are attached to the spindle. It binds to Cdc20 and prevents it from promoting destruction of an anaphase inhibitor, Securin. Previously, we showed that a Mad2-binding protein, p3...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Springer International Publishing
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3824705/ https://ncbi.nlm.nih.gov/pubmed/24255856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2193-1801-2-562 |
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