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A feed-forward loop involving Trib3, Akt and FoxO mediates death of NGF-deprived neurons
The mechanisms governing neuron death following NGF deprivation are incompletely understood. Here, we show that Trib3, a protein induced by NGF withdrawal, has a key role in such death via a loop involving the survival kinase Akt and FoxO transcription factors. Trib3 overexpression is sufficient to...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3824594/ https://ncbi.nlm.nih.gov/pubmed/24212932 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.128 |
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