載入...
A feed-forward loop involving Trib3, Akt and FoxO mediates death of NGF-deprived neurons
The mechanisms governing neuron death following NGF deprivation are incompletely understood. Here, we show that Trib3, a protein induced by NGF withdrawal, has a key role in such death via a loop involving the survival kinase Akt and FoxO transcription factors. Trib3 overexpression is sufficient to...
Na minha lista:
| Main Authors: | , , |
|---|---|
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2013
|
| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3824594/ https://ncbi.nlm.nih.gov/pubmed/24212932 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.128 |
| 標簽: |
添加標簽
沒有標簽, 成為第一個標記此記錄!
|