A feed-forward loop involving Trib3, Akt and FoxO mediates death of NGF-deprived neurons

The mechanisms governing neuron death following NGF deprivation are incompletely understood. Here, we show that Trib3, a protein induced by NGF withdrawal, has a key role in such death via a loop involving the survival kinase Akt and FoxO transcription factors. Trib3 overexpression is sufficient to...

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Main Authors: Zareen, N, Biswas, S C, Greene, L A
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2013
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Original Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824594/
https://ncbi.nlm.nih.gov/pubmed/24212932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.128
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