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Modeling the Synergy of Cofilin and Arp2/3 in Lamellipodial Protrusive Activity

Rapid polymerization of actin filament barbed ends generates protrusive forces at the cell edge, leading to cell migration. Two important regulators of free barbed ends, cofilin and Arp2/3, have been shown to work in synergy (net effect greater than additive). To explore this synergy, we model the d...

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Bibliografische gegevens
Hoofdauteurs: Tania, Nessy, Condeelis, John, Edelstein-Keshet, Leah
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Biophysical Society 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824550/
https://ncbi.nlm.nih.gov/pubmed/24209839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.09.013
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