A small-molecule blocking ribonucleotide reductase holoenzyme formation inhibits cancer cell growth and overcomes drug resistance

Ribonucleotide reductase (RNR) is an attractive target for anticancer agents given its central function in DNA synthesis, growth, metastasis, and drug resistance of cancer cells. The current clinically established RNR inhibitors have the shortcomings of short halflife, drug resistance, and iron chel...

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Detalhes bibliográficos
Main Authors: Zhou, Bingsen, Su, Leila, Hu, Shuya, Hu, Weidong, Yip, M. L. Richard, Wu, Jun, Gaur, Shikha, Smith, D. Lynne, Yuan, Yate-Ching, Synold, Timothy W., Horne, David, Yen, Yun
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3823501/
https://ncbi.nlm.nih.gov/pubmed/24072748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-1094
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