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ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage

Ribonucleotide reductase small subunit p53R2 was identified as a p53 target gene that provides dNTP for DNA damage repair. However, the slow transcriptional induction of p53R2 in RNA may not be rapid enough for prompt DNA damage repair, which has to occur within a few hours of damage. Here, we demon...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Chang, Lufen, Zhou, Bingsen, Hu, Shuya, Guo, Robin, Liu, Xiyong, Jones, Stephen N., Yen, Yun
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2008
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587585/
https://ncbi.nlm.nih.gov/pubmed/19015526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803313105
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