MEK2 regulates ribonucleotide reductase activity through functional interaction with ribonucleotide reductase small subunit p53R2

The p53R2 protein, a newly identified member of the ribonucleotide reductase family that provides nucleotides for DNA damage repair, is directly regulated by p53. We show that p53R2 is also regulated by a MEK2 (ERK kinase 2/MAP kinase kinase 2)-dependent pathway. Increased MEK1/2 phosphorylation by...

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Autori principali: Piao, Chunmei, Youn, Cha-Kyung, Jin, Min, Yoon, Sang Pil, Chang, In-Youb, Lee, Jung Hee, You, Ho Jin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3466523/
https://ncbi.nlm.nih.gov/pubmed/22895183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.21591
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