Ribonucleotide Reductase Subunit p53R2 Regulates Mitochondria Homeostasis and Function in KB and PC-3 Cancer Cells

Ribonucleotide reductase (RR) is a rate-limiting enzyme that catalyzes de novo conversion of ribonucleotide 5'-diphosphates to the corresponding 2'-deoxynucleotide, essential for DNA synthesis and replication. The mutations or knockout of RR small subunit, p53R2, results in the depletion o...

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Hlavní autoři: Wang, Xiaochen, Liu, Xiyong, Xue, Lijun, Zhang, Keqiang, Kuo, Mei-Ling, Hu, Shuya, Zhou, Bingsen, Ann, David, Zhang, Suzhan, Yen, Yun
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3180957/
https://ncbi.nlm.nih.gov/pubmed/21640705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2011.05.114
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