Loss of IKKβ activity increases p53 stability and p21 expression leading to cell cycle arrest and apoptosis

Elevated levels of NF-κB are frequently detected in many inflammatory diseases and cancers. Blocking the IKK–NF-κB pathway has been seen as a promising approach for new therapies. By employing the dominant-negative mutant of IKKβ, our data revealed that loss of IKKβ activity reduces not only the pro...

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Detalhes bibliográficos
Main Authors: Yang, Pei-Ming, Huang, Wei-Chien, Lin, Yi-Chu, Huang, Wen-Yu, Wu, Hui-Ann, Chen, Wei-Lun, Chang, Yu-Fan, Chou, Chia-Wei, Tzeng, Cherng-Chyi, Chen, Yeh-Long, Chen, Ching-Chow
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3823466/
https://ncbi.nlm.nih.gov/pubmed/19243472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2009.00712.x
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