Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120

A substantial fraction of broadly neutralizing antibodies (bnAbs) in certain HIV-infected donors recognizes glycan-dependent epitopes on HIV-1 gp120. Here, we elucidate how bnAb PGT 135 recognizes its Asn332 glycan-dependent epitope from its crystal structure with gp120, CD4 and Fab 17b at 3.1 Å res...

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Main Authors: Kong, Leopold, Lee, Jeong Hyun, Doores, Katie J., Murin, Charles D., Julien, Jean-Philippe, McBride, Ryan, Liu, Yan, Marozsan, Andre, Cupo, Albert, Klasse, Per-Johan, Hoffenberg, Simon, Caulfield, Michael, King, C. Richter, Hua, Yuanzi, Le, Khoa M., Khayat, Reza, Deller, Marc C., Clayton, Thomas, Tien, Henry, Feizi, Ten, Sanders, Rogier W., Paulson, James C., Moore, John P., Stanfield, Robyn L., Burton, Dennis R., Ward, Andrew B., Wilson, Ian A.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3823233/
https://ncbi.nlm.nih.gov/pubmed/23708606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2594
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