Enhanced internalization of ErbB2 in SK-BR-3 cells with multivalent forms of an artificial ligand

Targeting and down-regulation of ErbB2, a member of EGF receptor family, is regarded as one of the key aspect for cancer treatment because it is often overexpressed in breast and ovarian cancer cells. Although natural ligands for ErbB2 have not been found, unlike other ErbB receptors, EC-1, a 20-ami...

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Detalhes bibliográficos
Main Authors: Vaidyanath, Arun, Hashizume, Toshihiro, Nagaoka, Tadahiro, Takeyasu, Nao, Satoh, Hitomi, Chen, Ling, Wang, Jiyou, Kasai, Tomonari, Kudoh, Takayuki, Satoh, Ayano, Fu, Li, Seno, Masaharu
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2011
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3822962/
https://ncbi.nlm.nih.gov/pubmed/21323863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2011.01277.x
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