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Structural and thermodynamic insight into phenylalanine hydroxylase from the human pathogen Legionella pneumophila()

Phenylalanine hydroxylase from Legionella pneumophila (lpPAH) has a major functional role in the synthesis of the pigment pyomelanin, which is a potential virulence factor. We present here the crystal structure of lpPAH, which is a dimeric enzyme that shows high thermostability, with a midpoint dena...

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Detalhes bibliográficos
Main Authors: Leiros, Hanna-Kirsti S., Flydal, Marte Innselset, Martinez, Aurora
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3821034/
https://ncbi.nlm.nih.gov/pubmed/24251098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2013.08.006
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