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How Natalizumab Binds and Antagonizes α(4) Integrins
Natalizumab antibody to α(4)-integrins is used in therapy of multiple sclerosis and Crohn's disease. A crystal structure of the Fab bound to an α(4) integrin β-propeller and thigh domain fragment shows that natalizumab recognizes human-mouse differences on the circumference of the β-propeller d...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3820868/ https://ncbi.nlm.nih.gov/pubmed/24047894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.501668 |
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