Infectious Prions Accumulate to High Levels in Non Proliferative C2C12 Myotubes

Prion diseases are driven by the strain-specific, template-dependent transconformation of the normal cellular prion protein (PrP(C)) into a disease specific isoform PrP(Sc). Cell culture models of prion infection generally use replicating cells resulting in lower levels of prion accumulation compare...

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Bibliografiske detaljer
Main Authors: Herbst, Allen, Banser, Pamela, Velasquez, Camilo Duque, Mays, Charles E., Sim, Valerie L., Westaway, David, Aiken, Judd M., McKenzie, Debbie
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820720/
https://ncbi.nlm.nih.gov/pubmed/24244171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003755
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