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Replication of prions in differentiated muscle cells
We have demonstrated that prions accumulate to high levels in non-proliferative C2C12 myotubes. C2C12 cells replicate as myoblasts but can be differentiated into myotubes. Earlier studies indicated that C2C12 myoblasts are not competent for prion replication.(1) We confirmed that observation and dem...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Landes Bioscience
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4189884/ https://ncbi.nlm.nih.gov/pubmed/24518642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.27890 |
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