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Replication of prions in differentiated muscle cells

We have demonstrated that prions accumulate to high levels in non-proliferative C2C12 myotubes. C2C12 cells replicate as myoblasts but can be differentiated into myotubes. Earlier studies indicated that C2C12 myoblasts are not competent for prion replication.(1) We confirmed that observation and dem...

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Библиографические подробности
Главные авторы: Herbst, Allen, Aiken, Judd M, McKenzie, Debbie
Формат: Artigo
Язык:Inglês
Опубликовано: Landes Bioscience 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4189884/
https://ncbi.nlm.nih.gov/pubmed/24518642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.27890
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