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Site-Directed Mutagenesis of Catalytic Residues in N(5)-Carboxyaminoimidazole Ribonucleotide Synthetase
N(5)-CAIR synthetase, an essential enzyme in microorganisms, converts 5-aminoimidazole ribonucleotide (AIR) and bicarbonate to N(5)-CAIR with the aid of ATP. Previous X-ray crystallographic analyses of Aspergillus clavatus N(5)-CAIR synthetase postulated that R271, H273, and K353 were important for...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3820426/ https://ncbi.nlm.nih.gov/pubmed/23899325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400444y |
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