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Structural and biochemical characterization of N (5)-carboxyaminoimidazole ribonucleotide synthetase and N (5)-carboxyaminoimidazole ribonucleotide mutase from Staphylococcus aureus
With the rapid rise of methicillin-resistant Staphylococcus aureus infections, new strategies against S. aureus are urgently needed. De novo purine biosynthesis is a promising yet unexploited target, insofar as abundant evidence has shown that bacteria with compromised purine biosynthesis are attenu...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
International Union of Crystallography
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3144853/ https://ncbi.nlm.nih.gov/pubmed/21795812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444911023821 |
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