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The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons
Mutations in TDP-43 lead to familial ALS. Expanding evidence suggests that impaired mitochondrial dynamics likely contribute to the selective degeneration of motor neurons in SOD1-associated ALS. In this study, we investigated whether and how TDP-43 mutations might impact mitochondrial dynamics and...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3820133/ https://ncbi.nlm.nih.gov/pubmed/23827948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt319 |
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