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Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo
BACKGROUND: Mitochondrial dysfunction has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Functional studies of mitochondrial bioenergetics have focused mostly on superoxide dismutase 1 (SOD1) mutants, and showed that mutant human...
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| 發表在: | Mol Neurodegener |
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| Main Authors: | , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
BioMed Central
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5422931/ https://ncbi.nlm.nih.gov/pubmed/28482850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0180-1 |
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