A Single Mutation in a Regulatory Protein Produces Evolvable Allosterically Regulated Catalyst of Unnatural Reaction

[Image: see text] It only takes one mutation: a strategically placed single mutation in a non-enzymatic protein scaffold produced AlleyCat, a small, allosterically regulated catalyst of Kemp elimination. In only 7 rounds of directed evolution enzymatic efficiency of the original 74 amino acid residu...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Moroz, Olesia V., Moroz, Yurii S., Wu, Yibing, Olsen, Alissa B., Cheng, Hong, Mack, Korrie L., McLaughlin, Jaclyn M., Raymond, Elizabeth A., Zhezherya, Krystyna, Roder, Heinrich, Korendovych, Ivan V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3817844/
https://ncbi.nlm.nih.gov/pubmed/23630096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201302339
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados