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Biodistribution of newly synthesized PHEA-based polymer-coated SPION in Sprague Dawley rats as magnetic resonance contrast agent

OBJECTIVES: The purpose of this study was to observe the pharmacokinetic behavior of newly synthesized biocompatible polymers based on polyhydroxyethylaspartamide (PHEA) to be used to coat an iron oxide core to make superparamagnetic iron oxide nanoparticles (SPION). MATERIALS AND METHODS: The isoto...

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Bibliographic Details
Main Authors: Park, Junsung, Cho, Wonkyung, Park, Hee Jun, Cha, Kwang-Ho, Ha, Dae-Chul, Choi, Youn-Woong, Lee, Ha-Young, Cho, Sun-Hang, Hwang, Sung-Joo
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3817023/
https://ncbi.nlm.nih.gov/pubmed/24204138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S51684
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