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Mutation of a Single CTCF Target Site within the H19 Imprinting Control Region Leads to Loss of Igf2 Imprinting and Complex Patterns of De Novo Methylation upon Maternal Inheritance

The differentially methylated imprinting control region (ICR) region upstream of the H19 gene regulates allelic Igf2 expression by means of a methylation-sensitive chromatin insulator function. We have previously shown that maternal inheritance of mutated (three of the four) target sites for the 11-...

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Vydáno v:Mol Cell Biol
Hlavní autoři: Pant, Vinod, Kurukuti, Sreenivasulu, Pugacheva, Elena, Shamsuddin, Shaharum, Mariano, Piero, Renkawitz, Rainer, Klenova, Elena, Lobanenkov, Victor, Ohlsson, Rolf
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2004
Témata:
Gene Expression
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC381662/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15060168/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.8.3497-3504.2004
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