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Mutation of a Single CTCF Target Site within the H19 Imprinting Control Region Leads to Loss of Igf2 Imprinting and Complex Patterns of De Novo Methylation upon Maternal Inheritance

The differentially methylated imprinting control region (ICR) region upstream of the H19 gene regulates allelic Igf2 expression by means of a methylation-sensitive chromatin insulator function. We have previously shown that maternal inheritance of mutated (three of the four) target sites for the 11-...

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Publicado no:Mol Cell Biol
Principais autores: Pant, Vinod, Kurukuti, Sreenivasulu, Pugacheva, Elena, Shamsuddin, Shaharum, Mariano, Piero, Renkawitz, Rainer, Klenova, Elena, Lobanenkov, Victor, Ohlsson, Rolf
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2004
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC381662/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15060168/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.8.3497-3504.2004
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